Regioselective palladium-catalyzed aminations of 3,5-dibromo-2-pyrone with various aryl and alkyl amines

3,5-Dibromo-2-pyrone underwent facile palladium-catalyzed coupling reactions with various primary and secondary alkyl and aryl amines to furnish a variety of the previously unknown 3-arylamino- and 3-alkylamino-5-bromo-2-pyrones with good to excellent regioselectivity and chemical yields.