Author/Authors :
Cooper، نويسنده , Paul W , Ian R. and Grigg، نويسنده , , Ronald and MacLachlan، نويسنده , , William S. and Sridharan، نويسنده , , Visuvanathar and Thornton-Pett، نويسنده , , Mark، نويسنده ,
Abstract :
A new diastereo-and regioselective Pd/In bimetallic cascade process which assembles three contiguous chiral centres is described. Pd(0)-catalysed cyclisation of aryl iodides onto proximate 1,3-dienes generates π-allylpalladium(II) species, transmetallation with indium and subsequent Barbier-type addition to aldehydes affords heterocyclic homoallylic alcohols.
