• Title of article

    Rapid synthesis of 11C-labeled FK506 for positron emission tomography

  • Author/Authors

    Murakami، نويسنده , , Yoshihiro and Kuroda، نويسنده , , Akio and Osoda، نويسنده , , Kazuhiko and Nishimura، نويسنده , , Shintaro، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2003
  • Pages
    4
  • From page
    641
  • To page
    644
  • Abstract
    The present study describes a rapid synthesis method for labeled [11C]FK506 for positron emission tomography (PET). A one-pot reaction from [11C]CH3I, involving a Wittig reaction as the key carboncarbon bond formation was developed. The chemical process was accomplished using a designed, fully automated synthetic apparatus, and an injectable solution of [11C]FK506 was obtained in only 34 min from [11C]CH3I. The decay-corrected radiochemical yield based on [11C]CH3I was 11.9%, and the specific activity was 39.8 GBq/μmol.
  • Keywords
    PET , FK506 , 11C , Wittig reaction
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2003
  • Journal title
    Tetrahedron Letters
  • Record number

    1660192

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1660192