Title of article
Synthesis and aromatic nucleophilic N–N, N–S and N–O exchange reactions of N,N-dimethyl-2-trifluoroacetyl-1-naphthylamine
Author/Authors
Okada، نويسنده , , Etsuji and Otsuki، نويسنده , , Yoshihiro and Shinohara، نويسنده , , Megumi and Médebielle، نويسنده , , Maurice and Shimizu، نويسنده , , Yuhei and Takeuchi، نويسنده , , Hiroshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
741
To page
744
Abstract
We succeeded in the synthesis of N,N-dimethyl-2-trifluoroacetyl-1-naphthylamine (10) by the regioselective deacylation of N,N-dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine with trifluoroacetic acid and water. The aromatic nucleophilic substitutions of 10 with various amines, thiols and alcohols proceeded cleanly to give the corresponding N–N, N–S and N–O exchanged products in moderate to excellent yields.
Keywords
regioselective deacylation , acid-catalyzed reaction , Aromatic nucleophilic substitution , trifluoroacetylated naphthalenes , Fluorine compounds
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1660263
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