Author/Authors :
Santagada، نويسنده , , Vincenzo and Fiorino، نويسنده , , Ferdinando and Perissutti، نويسنده , , Elisa and Severino، نويسنده , , Beatrice and Terracciano، نويسنده , , Sara and Cirino، نويسنده , , Giuseppe and Caliendo، نويسنده , , Giuseppe، نويسنده ,
Abstract :
A novel and convenient microwave-assisted dimerization of an active peptide compound using the DKPs as scaffold is described. The key reaction giving rise to the diketopiperazine scaffold is the intermolecular coupling. No epimerization was detected in the reactions used. Conventional and microwave heating of the reactions are compared. Synthesis by microwave irradiation gave the desired compounds in higher yields and in shorter reaction times than those obtained by conventional heating.
