Floresolides, new metacyclophane hydroquinone lactones from an ascidian, Aplidium sp

Three new cyclofarnesylated hydroquinones, floresolides A–C (2–4), have been isolated from an ascidian, Aplidium sp. and the structures determined by spectroscopic and X-ray diffraction analysis. Floresolides possessing an ε-lactone bridging the aromatic ring and a [10]metacyclophane band are unique members of the class of compounds known as longithorones and longithorols from Aplidium longithorax.