Author/Authors :
Kasanah، نويسنده , , Noer and Rao، نويسنده , , Karumanchi V. and Yousaf، نويسنده , , Muhammad and Wedge، نويسنده , , David E. and Hamann، نويسنده , , Mark T.، نويسنده ,
Abstract :
The selective dehydroxylation of 8-hydroxymanzamine A (1) to form manzamine A (2) can be completed by fermentation with Fusarium solani or Streptomyces seokies. This unique biocatalytic conversion is important due to the fact that manzamine A has more desirable biological activity when assayed in a murine model against malaria.
Keywords :
8-hydroxymanzamine A , selective dehydroxylation , Fusarium Solani , Streptomyces seokies
