Author/Authors :
Shimada، نويسنده , , Yumi and Nakamura، نويسنده , , Makoto and Suzuka، نويسنده , , Toshimasa and Matsui، نويسنده , , Junji and Tatsumi، نويسنده , , Ryo and Tsutsumi، نويسنده , , Ken and Morimoto، نويسنده , , Tsumoru and Kurosawa، نويسنده , , Hideo and Kakiuchi، نويسنده , , Kiyomi، نويسنده ,
Abstract :
A new method for the construction of the AB-ring core of Taxol was developed utilizing a new skeletal transformation protocol as a pivotal step. The acid-catalyzed rearrangement of the cyclopentenone–allene photoadduct gave a bridged seven-membered ketone, which was easily transformed, using the intramolecular Suzuki reaction and the oxidative cleavage of the vicinal diol, to the bicyclic diketone.
