Title of article
Trimethylsilyl derivatives of N4-Boc-cytosine and their effect on I2-mediated nucleosidation of O-MTM ethers
Author/Authors
Huang، نويسنده , , Yumei and Dey، نويسنده , , Subhakar and Garner، نويسنده , , Philip، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
1441
To page
1444
Abstract
Mono- and bis(trimethylsilyl) derivatives of N4-Boc-cytosine were synthesized and characterized by 1H NMR. Only the mono(trimethylsilyl)-N4-Boc-cytosine participates in the iodine-mediated nucleosidation of N-Fmoc-O-methylthiomethyl serine benzyl ester to produce the cytosine nucleoamino acid, while the bis(trimethylsilyl) derivative failed to give any product. A tentative mechanistic explanation is proposed.
Keywords
NMR , nucleosidation , N4-Boc-cytosine , Silylation
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1660645
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