Title of article
Synthesis and antitumor activity of DNA binding cationic porphyrin–platinum(II) complexes
Author/Authors
Song، نويسنده , , Rita and Kim، نويسنده , , Yeong-Sang and Lee، نويسنده , , Chong Ock and Sohn، نويسنده , , Youn Soo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
1537
To page
1540
Abstract
A new series of DNA binding 5,10,15-tri(N-methyl-4-pyridiniumyl)porphyrin (TrisMPyP)-platinum(II) conjugates was synthesized, in which different spacer ligands were used for appropriate coordination to platinum(II) complexes. Compound 9b exhibited in vivo antitumor activity (T/C%, 294) superior to cisplatin (T/C%, 184) against the leukemia L1210 cell line.
Keywords
Porphyrin , Antitumor agent , Platinum(II) , DNA binding
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1660710
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