Title of article
A complete asymmetric synthesis of polyhydroxypiperidines
Author/Authors
Han، نويسنده , , Hyunsoo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
1567
To page
1569
Abstract
A new general methodology for the asymmetric synthesis of polyhydroxypiperidines is described. The readily available achiral olefin 4 was transformed to 5-des(hydroxymethyl)-1-deoxynojirimycin (1) and its mannose analog 10 via regioselective aminohydroxylation (AA), ring-closing metathesis (RCM), and diastereoselective dihydroxylation reactions. Thus, the developed methodology made it possible to install all stereocenters in 1 and 10 in a highly stereocontrolled fashion.
Keywords
polyhydroxypiperidine , regioselective aminohydroxylation , ring-closing metathesis
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1660728
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