Author/Authors :
Stevens، نويسنده , , Christian V. and Vekemans، نويسنده , , Wannes and Moonen، نويسنده , , Kristof and Rammeloo، نويسنده , , Thomas، نويسنده ,
Abstract :
4-Aryl-4-phosphono-β-lactams are prepared by acylation of iminium salts with chloroacetyl chloride followed by phosphite addition and ring closure using sodium hydride as a base. Deacylation of the iminium salt is in competition with the desired addition of phosphites to acyliminium salts, which lowers the yield of the reaction.
