Title of article
Synthesis and bioactivities of paclitaxel analogs with a cyclopropanated side-chain
Author/Authors
Liu، نويسنده , , Changhui and Tamm، نويسنده , , Markus and Nِtzel، نويسنده , , Marcus W. and de Meijere، نويسنده , , Armin and Schilling، نويسنده , , Jennifer K. and Kingston، نويسنده , , David G.I.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
2049
To page
2052
Abstract
Four paclitaxel analogs with a cyclopropanated side-chain were synthesized by coupling of the spirocyclopropanated oxazoline-5-carboxylic acid 4 with 7-TES-baccatin III, followed by hydrolytic ring opening and rearrangement. The absolute configuration of the 2′-position was determined by NMR analysis of the corresponding Mosher esters. The two new paclitaxel analogs with the R configuration at C-2′ were both active in the A2780 mammalian cell line cytotoxicity assay, but much less than paclitaxel itself.
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661015
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