Chemoenzymatic polymer-supported liquid phase synthesis of glucose γ-aminobutyric ester

A concise, polymer-supported solution synthesis of 6-O-(γ-aminobutyryl)-d-glucose has been achieved. Glucose was attached to polyethylene glycol monomethyl ether (MPEG) through an α,α′-dioxyxylyl diether linker, and, subsequently, the HO-6 hydroxyl of the glucose was regioselectively esterified with γ-aminobutyric acid by a lipase-catalyzed reaction.