Title of article
A novel and convenient method for the synthesis of substituted naphthostyrils
Author/Authors
Liu، نويسنده , , Jin-Jun and Konzelmann، نويسنده , , Fred and Luk، نويسنده , , Kin-Chun Luk، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
2545
To page
2548
Abstract
3-Pyrrolyl-6-fluoro-naphthostyril 13 was synthesized via a base-catalyzed intramolecular cyclization of oxindole precursor 2 (Y=H). Derivatization of 2 (Y=I) through a one-pot reaction give 5-substituted naphthostyrils. This method allows convenient access to 3,5,6-trisubstituted naphthostyrils which may serve as a new template for CDK2 inhibition.
Keywords
naphthostyril , Intramolecular cyclization , cross-coupling , CDK2 inhibition
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661324
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