Title of article
Rapid cyclopeptide analysis by microwave enhanced Akabori reaction
Author/Authors
Pramanik، نويسنده , , Birendra N. and Ing، نويسنده , , Yao Hain and Bose، نويسنده , , Ajay K. and Zhang، نويسنده , , Li-Kang and Liu، نويسنده , , Yan-Hui and Ganguly، نويسنده , , Subhendu N. and Bartner، نويسنده , , Peter، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
2565
To page
2568
Abstract
The application of microwave assisted modification of the Akabori hydrazinolysis reaction has been found to cleave cyclic oligopeptides in a selective fashion to produce mainly the hydrazide of a specific linear peptide. This ring cleavage requires a few minutes of reaction in a domestic microwave oven. The linear peptide hydrazide can be analyzed by ESI-MS/MS, FAB-MS, and FAB-MS/MS methods for the determination of the amino acid sequence.
Keywords
Akabori reaction , Hydrazinolysis , cyclopeptides , amino acid sequence , microwave enhanced reaction
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661340
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