Author/Authors :
Zhu، نويسنده , , Qing and Huang، نويسنده , , Xuan and Chen، نويسنده , , Grace Y.J and Yao، نويسنده , , Shao Q. Yao، نويسنده ,
Abstract :
We have successfully designed and synthesized two fluorescently-labeled, activity-based probes, Probe 1 and Probe 2, which were shown to label protein tyrosine phosphatases specifically, as well as other types of phosphatases. The probes were not reactive towards the other non-phosphatase enzymes tested. These probes may find potential applications in large-scale proteomic experiments whereby subclasses of proteins may be selectively identified.
