Title of article :
The total synthesis of (−)-tetrahydrolipstatin
Author/Authors :
Bodkin، نويسنده , , Jennifer A and Humphries، نويسنده , , Edward J and McLeod، نويسنده , , Malcolm D، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
Careful control during the bromolactonisation of β,γ-unsaturated acid 3 was required to afford regioselectively the trans-β-lactone 4 as the major diastereomer. Radical debromination of 4 followed by a three-step sequence of reactions afforded the lipase inhibitor (−)-tetrahydrolipstatin.
Keywords :
(?)-tetrahydrolipstatin , bromolactonisation , radical dehalogenation , ?-Lactone
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
