Title of article
An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles
Author/Authors
Engler، نويسنده , , Thomas A. and Furness، نويسنده , , Kelly and Malhotra، نويسنده , , Sushant and Diefenbacher، نويسنده , , Clive R. Clayton، نويسنده , , Joshua R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
2903
To page
2905
Abstract
Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI2 to give heteroaryl-acetonitriles in generally good overall yields (50–100%). The generality of the process is demonstrated.
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661541
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