Author/Authors :
Engler، نويسنده , , Thomas A. and Furness، نويسنده , , Kelly and Malhotra، نويسنده , , Sushant and Diefenbacher، نويسنده , , Clive R. Clayton، نويسنده , , Joshua R.، نويسنده ,
Abstract :
Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI2 to give heteroaryl-acetonitriles in generally good overall yields (50–100%). The generality of the process is demonstrated.
