Author/Authors :
Conde، نويسنده , , Jose J. and McGuire، نويسنده , , Michael and Wallace، نويسنده , , Michael، نويسنده ,
Abstract :
Osteoclast inhibitor SB-242784 (1) was prepared from pivotal indol intermediate 4. A ‘Stille’ cross coupling of organotin 2c with bromo acrylate 11 afforded diene 12 which was also obtained via a reduction–isomerization process of enyne 16. Bromoamide 3 was prepared from the corresponding acid 7 which was readily obtained from bromopyruvic acid.
