Author/Authors :
Kato، نويسنده , , Keisuke and Tanaka، نويسنده , , Maki and Yamamura، نويسنده , , Shigeo and Yamamoto، نويسنده , , Yasuhiro and Akita، نويسنده , , Hiroyuki، نويسنده ,
Abstract :
The first example of asymmetric cyclization–carbonylation of 2-propargyl-1,3-dione 1 catalyzed by palladium(II) with chiral bisoxazolines (C.H.-BOX) was investigated. The use of bulky alcohols increased the ee of the products 2. The product 2d was converted into bicyclic enones 7 and 8, a useful intermediate for the synthesis of natural products.
