Author/Authors :
Garcia-Castro، نويسنده , , Ivette and Tillack، نويسنده , , Annegret and Hartung، نويسنده , , Christian G and Beller، نويسنده , , Matthias، نويسنده ,
Abstract :
The one-pot synthesis of several branched secondary aliphatic amines is described. Hydroamination of terminal alkynes with aliphatic primary amines in the presence of Cp2Ti(η2-Me3SiCCSiMe3) gives the corresponding aldimines as intermediates. Reaction of these in situ produced aldimines with organolithium reagents (n-BuLi, PhLi) provides the α-branched amines in an easy way in upto 78% overall yield.
