Title of article :
Efficient and convergent stereocontrolled spiroannulation of ketones
Author/Authors :
Markَ، نويسنده , , Istvلn E. and Vanherck، نويسنده , , Jean-Christophe and Ates، نويسنده , , Ali and Tinant، نويسنده , , Bernard and Declercq، نويسنده , , Jean-Paul، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
Upon treatment with tBuOK/H2O, a variety of ω-halo-β-keto-ketals undergo smooth cyclisation, affording in excellent yields mono-protected [n,m] spiro bicyclic diketones. This transformation is highly stereoselective producing, in all cases, the diastereoisomerically pure spiro derivatives.
Keywords :
stereocontrol , orthoesters , spirobicycle , annulation , Alkylation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
