Title of article :
4-Amino-1-oxyl-2,2,6,6-tetramethylpiperidine-3-carboxylic acid (β-TOAC), the first spin-labelled, cyclic, chiral β-amino acid resolved in an enantiomerically pure state
Author/Authors :
Wright، نويسنده , , Karen and Crisma، نويسنده , , Marco and Toniolo، نويسنده , , Claudio and Tِrِk، نويسنده , , Roland and Péter، نويسنده , , Antal and Wakselman، نويسنده , , Michel and Mazaleyrat، نويسنده , , Jean-Paul، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
Amination of 3-carboxymethyl-1-oxyl-2,2,6,6-tetramethyl-4-piperidone with (R)-α-methylbenzylamine, NaBH3CN reduction of the resulting enamine and removal of the chiral auxiliary from the separated diastereoisomers, led to enantiomerically pure (3S,4S) and (3R,4R) methyl 4-amino-1-oxyl-2,2,6,6-tetramethylpiperidine-3-carboxylates.
Keywords :
modified ?-amino acids , spin-labelled amino acids , chiral nitroxides
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
