Author/Authors :
Segraves، William A. نويسنده , , Nathaniel L and Lopez، نويسنده , , Suzette and Johnson، نويسنده , , Tyler A and Said، نويسنده , , Sadri A and Fu، نويسنده , , Xiong and Schmitz، نويسنده , , Francis J and Pietraszkiewicz، نويسنده , , Halina and Valeriote، نويسنده , , Frederick A and Crews، نويسنده , , Phillip، نويسنده ,
Abstract :
The structural variations and bioactivity properties of the alkaloids in the fascaplysin (1) and the reticulatine (3) families were examined. Four organisms were analyzed consisting of two collections of the sponge Fascaplysinopsis reticulata and two collections of the tunicate Didemnum sp. Reported are the isolation of three new compounds: 3-bromofascaplysin (2), 14-bromoreticulatine (4), and 14-bromoreticulatate (6) along with reticulatate (5) previously known as a semi-synthetic product of 1. Compounds 1 and 5 showed selectivity in a cell based cytotoxicity assay.
Keywords :
Didemnum , fascaplysin , Fascaplysinopsis , tunicate , alkaloid , Sponge
