Title of article
Synthesis of 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-ones utilizing activated alkynoates
Author/Authors
Harriman، نويسنده , , Geraldine C.B and Chi، نويسنده , , Shannon and Zhang، نويسنده , , Min and Crowe، نويسنده , , Andrea and Bennett، نويسنده , , Robert W. and Parsons، نويسنده , , Ian، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
3659
To page
3662
Abstract
The synthesis of the biologically relevant, 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one 7, is reported. Addition of substituted 2-aminopyridines 5 to activated alkynoates leads to the facile formation of a series of metabolically stable trifluoromethyl substituted pyrido[1,2-a]pyrimidines under mild conditions.
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661983
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