Title of article :
First access to the spin-labelled β-amino acid POAC in an enantiopure state by resolution through its binaphthyl esters
Author/Authors :
Wright، نويسنده , , Karen and Formaggio، نويسنده , , Fernando and Toniolo، نويسنده , , Claudio and Tِrِk، نويسنده , , Roland and Péter، نويسنده , , Antal and Wakselman، نويسنده , , Michel and Mazaleyrat، نويسنده , , Jean-Paul، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
Resolution of trans 3-(9-fluorenylmethyloxycarbonylamino)-1-oxyl-2,2,5,5-tetramethylpyrrolidine-4-carboxylic acid (Fmoc-POAC-OH) was quickly achieved upon esterification with (aR)-1,1′-binaphthyl-2,2′-diol, chromatographic separation of the obtained diastereomers, and facile saponification of the aryl ester function with removal of the chiral auxiliary.
Keywords :
binaphthol esters , spin-labelled amino acids , modified ?-amino acids , POAC , chiral nitroxides , RESOLUTION
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
