Author/Authors :
Wang، نويسنده , , Jianji and Discordia، نويسنده , , Robert P. and Crispino، نويسنده , , Gerard A. and Li، نويسنده , , Jun and Grosso، نويسنده , , John A. and Polniaszek، نويسنده , , Richard and Truc، نويسنده , , Vu C.، نويسنده ,
Abstract :
Using LiHMDS as the base, a tandem amidation/Knoevenagel condensation of 2-aminobenzophenones with α-methylene esters or lactones gives 4-aryl-quinolin-2(1H)-ones in 65–96% yield. This method is mild, highly efficient, and amenable to scaleup.
