Author/Authors :
Mase، نويسنده , , Nobuyuki and Sako، نويسنده , , Takeshi and Horikawa، نويسنده , , Yoshiteru and Takabe، نويسنده , , Kunihiko، نويسنده ,
Abstract :
In lipase-catalyzed asymmetrization of 1,3-propanediacetate no enantioselectivity was observed in conventional organic solvents, whereas in supercritical carbon dioxide (scCO2) enantioselectivities were observed up to 50% ee, which probably arose from a conformational changing of lipase at the active site due to a transformation of the amino group of lysine into carbamic acid.
