Author/Authors :
Shang، نويسنده , , Qian and Xiang، نويسنده , , Jun-Feng and Zhang، نويسنده , , Xiu-Feng and Sun، نويسنده , , Hongxia and Li، نويسنده , , Lin and Tang، نويسنده , , Ya-Lin، نويسنده ,
Abstract :
Screening G-quadruplex ligands from natural plants is important because the ligands may be potential antitumor drugs. A new screening strategy is proposed based on the combination of dialysis and G-quadruplex recognition technique which could separates G-quadruplex ligand from natural extracts and elucidate the structure of this ligand. This result offers a novel approach to obtain active antitumor compounds.
Keywords :
Natural plant extracts , Dialysis , G-quadruplex recognition , NMR spectroscopy , Separation
