Author/Authors :
Obika، نويسنده , , Satoshi and Andoh، نويسنده , , Jyun-ichi and Onoda، نويسنده , , Mayumi and Nakagawa، نويسنده , , Osamu and Hiroto، نويسنده , , Akiko and Sugimoto، نويسنده , , Tomomi and Imanishi، نويسنده , , Takeshi، نويسنده ,
Abstract :
A novel bridged nucleic acid monomer, 3′-amino-3′-deoxy-5-methyl-3′-N,4′-C-methyleneuridine, was successfully synthesized via a useful and convenient azetidine ring formation under Staudingerʹs conditions. A 1H NMR experiment and a PM3 calculation revealed that the sugar moiety of the novel bridged nucleic acid monomer, 3′-amino-3′,4′-BNA, was restricted to S-type conformation.
