Author/Authors :
Kantor-Boruta، نويسنده , , Ma?gorzata and Lisowska-Ku?micz، نويسنده , , Ma?gorzata and Jo?czyk، نويسنده , , Anna and Siedlecka، نويسنده , , Joanna and Ocios-B?benek، نويسنده , , Agnieszka and Jaro?czyk، نويسنده , , Ma?gorzata and Mazurek، نويسنده , , Aleksander P. and Ksyci?ska، نويسنده , , Hanna and Chilmonczyk، نويسنده , , Zdzis?aw and Jarosz، نويسنده , , Maciej، نويسنده ,
Abstract :
New chromatographic method for the enantioseparation of (R,S)-tamsulosin and the determination of (R)- and (S)-tamsulosin was developed with the aid of amylose tris(3,5-dimethylphenylcarbamate) stationary phase. The method was compared to the known procedure for tamsulosin enantioseparation on cellulose tris(3,5-dimethylphenyl carbamate). Careful validation of both methods allowed to prove advantages of the new procedure: significantly better resolution as well as twice better sensitivity. The method was applied to quantification of (R)- and (S)-tamsulosin contents in prolonged release Apo-Tamis 0.4 mg hard capsules (Apotex Europe B.V) and Omnic Ocas 0.4 mg coated tablets (Astellas).
Keywords :
Chiral separation , Amylose tris(3 , HPLC , Tamsolusin , Enantiomers , 5-dimethylphenylcarbamate)
