Author/Authors :
Miller، نويسنده , , Philip R. and Skoog، نويسنده , , Shelby A. and Edwards، نويسنده , , Thayne L. and Lopez، نويسنده , , Deanna M. and Wheeler، نويسنده , , David R. and Arango، نويسنده , , Dulce C. and Xiao، نويسنده , , Xiaoyin and Brozik، نويسنده , , Susan M. and Wang، نويسنده , , Joseph and Polsky، نويسنده , , Ronen and Narayan، نويسنده , , Roger J.، نويسنده ,
Abstract :
The development of a microneedle-based biosensor array for multiplexed in situ detection of exercise-induced metabolic acidosis, tumor microenvironment, and other variations in tissue chemistry is described. Simultaneous and selective amperometric detection of pH, glucose, and lactate over a range of physiologically relevant concentrations in complex media is demonstrated. Furthermore, materials modified with a cell-resistant (Lipidure®) coating were shown to inhibit macrophage adhesion; no signs of coating delamination were noted over a 48-h period.
Keywords :
Multiplexed detection , Carbon paste , Tumor microenvironment , Microneedle , Microneedle biosensor
