Selective voltammetric determination of d-penicillamine in the presence of tryptophan at a modified carbon paste electrode incorporating TiO2 nanoparticles and quinizarine

A carbon paste electrode (CPE) chemically modified with TiO2 nanoparticles and quinizarine (QZ) was used as a selective electrochemical sensor for the simultaneous determination of minor amounts of d-penicillamine (D-PA) and tryptophan (Trp). This modified electrode showed very efficient electrocatalytic activity for anodic oxidation of both d-PA and Trp. Substantial decreases of anodic overpotentials for both compounds made this analysis possible. Results of square wave voltammetry (SWV) using this modified electrode showed two well-resolved anodic waves for the oxidation of d-PA and Trp, which makes the simultaneous determination of both compounds possible. The peak potential for the oxidation of d-PA was lowered by at least 220 mV compared with that obtained for an unmodified CPE. In optimal conditions, linear ranges spanned a d-PA concentration from 0.8 μM to 140.0 μM and the detection limit was 0.76 μM at a signal-to-noise ratio of 2. In addition, the sensor had good stability and reproducibility.