Title of article :
Effect of process parameters on the melt granulation of pharmaceutical powders
Author/Authors :
Walker، نويسنده , , G.M. and Andrews، نويسنده , , G. and Jones، نويسنده , , D.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Co-melt granulation of lactose and PEG was investigated in a fluidised bed granulator. The effect of process parameters such as binder content and binder viscosity were correlated to granulation time and particle size distribution. The experimental data indicated that after initial nucleation the granulation mechanism was dependent upon binder content and binder viscosity. When the binder content was increased above 18% (w/w) de-fluidisation of the bed occurred and granulation moved to the slurry regime. As the process involved the melt granulation of relatively high molecular weight (6–20 k) and thus high viscosity PEG (500–19000 mPa s), it was found that binder viscosity had a significant affect on the granule growth mechanism. Granulation with a binder viscosity of 500 mPa s resulted in granule growth by coalescence, however, an increase in binder viscosity resulted in less coalescence and a lower granule growth rate. Furthermore, the granulation data were characterised by Stokes number analysis.
Keywords :
Melt granulation , Granule growth regimes , Stokes number , Pharmaceutical powders
Journal title :
Powder Technology
Journal title :
Powder Technology