Author/Authors :
Ishii، نويسنده , , Akira and Kurihara، نويسنده , , Rina and Watanabe-Suzuki، نويسنده , , Kanako and Kumazawa، نويسنده , , Takeshi and Seno، نويسنده , , Hiroshi and Matsushima، نويسنده , , Hajime and Suzuki، نويسنده , , Osamu and Katsumata، نويسنده , , Yoshinao، نويسنده ,
Abstract :
We have presented a simple and sensitive method for determining pethidine, a narcotic analgesic drug in body fluids by gas chromatography (GC)/surface ionization organic mass spectrometry (SIOMS). Good linearity was obtained in the range of 0.625–25 ng/ml of whole blood and urine by mass chromatography, and in the range of 0.05–2 ng/ml of whole blood by selected ion monitoring (SIM). Pethidine and diphenylpyraline (internal standard) were extracted from body fluids with Bond Elut Certify cartridges; their recoveries were above 95%. The detection limits (signal-to-noise ratio=3) were estimated to be 0.2 ng/ml of whole blood or urine by mass chromatography, 0.02 ng/ml of whole blood by SIM.
