Title of article :
Investigations into the interaction between tumor-inhibiting ruthenium(III) complexes and nucleotides by capillary electrophoresis
Author/Authors :
Küng، نويسنده , , Angelika and Pieper، نويسنده , , Thomas and Keppler، نويسنده , , Bernhard K، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
9
From page :
81
To page :
89
Abstract :
Ruthenium(III) complexes of the general formula HL[RuCl4L2], with two trans-standing heterocyclic ligands L bound to ruthenium via nitrogen, show remarkable activity in different tumor models. To obtain a deeper insight into the mode of action of this class of anticancer compounds, we investigated the interaction of HIm trans-[RuCl4(im)2] (im, imidazole) and HInd trans-[RuCl4(ind)2] (ind, indazole) with all four nucleoside monophosphates in buffered solution by means of capillary electrophoresis. A preference for GMP- and AMP-coordination was found. A decrease of the pH resulted in a significantly increased amount of bound nucleotide. This feature seems to be interesting with regard to the lower pH values in solid tumors.
Keywords :
Ruthenium(III) , Nucleotides
Journal title :
Journal of Chromatography B Biomedical Sciences and Applications
Serial Year :
2001
Journal title :
Journal of Chromatography B Biomedical Sciences and Applications
Record number :
1705479
Link To Document :
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