Title of article
Microbial reduction of cyclohexanones
Author/Authors
De Conti، نويسنده , , Roseli Maria and Porto، نويسنده , , André L.M. and Augusto، نويسنده , , J. and Rodrigues، نويسنده , , R. and Moran، نويسنده , , Paulo J.S. and Manfio، نويسنده , , Gilson P. and Marsaioli، نويسنده , , Anita J.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
233
To page
236
Abstract
A Brazilian strain of the bacteria Serratia rubidaea CCT 5742 quantitatively reduced 4-tert-butylcyclohexanone and 4-methylcyclohexanone to the less thermodynamically stable diastereoisomeric alcohols cis-4-tert-butylcyclohexanol and cis-4-methylcyclohexanol with a diastereoisomeric excesses (de) of 96% and 44%, respectively. 2-Methylcyclohexanone was also totally reduced to the corresponding alcohols affording the trans-(+)-(1S, 2S)-2-methylcyclohexanol with 78% of de and an enantiomeric excess (ee) of 80%. The cis-(+)-(1S, 2R)-2-methylcyclohexanol was obtained in 98% ee.
Keywords
Diastereo- and enantioselective reductions , cyclohexanones , Serratia rubidaea
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2001
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1708574
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