Inhibition of digestive lipases by 2-oxo amide triacylglycerol analogues

Potent and specific inhibitors of digestive lipases are of interest because they contribute to the understanding of the molecular mechanism of lipase action, and they may also find medical applications. In this review, results obtained by our group concerning the design and synthesis of 2-oxo amide triacylglycerol analogues will be discussed, and a study of their inhibition effect on pancreatic and gastric lipases will be presented.