Title of article
Regioselective enzymatic acylation of N-acetylhexosamines
Author/Authors
Pavla Simerska، نويسنده , , Pavla and Pi?vejcov?، نويسنده , , Andrea and Kuzma، نويسنده , , Marek and Sedmera، نويسنده , , Petr and K?en، نويسنده , , Vladim??r and Nicotra، نويسنده , , Silvia and Riva، نويسنده , , Sergio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
7
From page
219
To page
225
Abstract
A careful choice of the reaction conditions (solvent, enzyme, acylating agent) allowed an efficient regioselective acylation of N-acetylhexosamines. 6-O-Acyl derivatives of 2-acetamido-2-deoxy-d-glucopyranose (GlcNAc), 2-acetamido-2-deoxy-d-galactopyranose (GalNAc) and 2-acetamido-2-deoxy-d-mannopyranose (ManNAc) have been isolated from regioselective esterifications catalysed by the protease subtilisin in CH3CN–DMSO 8:2 in good yields.
Keywords
N-Acetylhexosamines , regioselectivity , Enzymatic acylation , SUBTILISIN , DMSO
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2004
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1710248
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