Biotransformation of 5α-hydroxy-14-eudesm-11-en-3-one by Rhizopus nigricans, Cunninghamella elegans and Mucor plumbeus

5α-Hydroxy-14-eudesm-11-en-3-one (1) was metabolised by the filamentous fungi Rhizopus nigricans, Cunninghamella elegans and Mucor plumbeus to produce four metabolites. Regioselective hydroxylation at C-6 and C-11 were detected. These 11-hydroxylated compounds can be chemically transformed into α-agarofuran.