Multi-substrate screening for lipase-catalyzed resolution of arylalkylethanols with succinic anhydride as acylating agent

CAL-B lipase-catalyzed resolution of a number of arylalkylethanols using succinic anhydride as acylating agent has been performed to evaluate the corresponding enantioselectivity factors. Then “one-pot multi-substrate screening” reactions involving two- and four-substrate mixtures were carried out and evaluation of the enantioselectivity factors for each alcohol was undertook by a single-run analysis. It was concluded that the alcohols in the mixture behave independently, validating the “one-pot multi-substrate screening” for a rapid evaluation of the enantioselectivity of the kinetic resolution process for each individual substrate.