Title of article :
Selectivity of penicillin G acylase towards phenylacetic acid derivatives in amide bond synthesis in toluene
Author/Authors :
Basso، نويسنده , , Alessandra and De Martin، نويسنده , , Luigi and Ebert، نويسنده , , Cynthia and Gardossi، نويسنده , , Lucia and Linda، نويسنده , , Paolo، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
8
From page :
73
To page :
80
Abstract :
Penicillin G acylase (PGA) accepts in toluene several analogues of phenylacetic acid as acyl donors. The 4-hydroxyphenylacetic group is preferentially accepted, and steric factors, such as the substitution at the aromatic ring or at the methylene group, cause a remarkable reduction in the initial rates. Results indicate that the selectivity follows a similar trend both in toluene and in aqueous media and that the synthetic potential of PGA can be fully exploited also in non-aqueous media with the consequent advantages, such as the absence of competitive hydrolytic reactions, higher solubility of phenylacetic derivatives and the possibility of working with equimolar amounts of reactants.
Keywords :
Penicillin G acylase , Phenylacetic analogues , acylation , Organic solvent , water activity
Journal title :
Journal of Molecular Catalysis B Enzymatic
Serial Year :
2001
Journal title :
Journal of Molecular Catalysis B Enzymatic
Record number :
1715906
Link To Document :
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