Author/Authors :
To?a، نويسنده , , Monica and Paizs، نويسنده , , Csaba and Majdik، نويسنده , , Cornelia and Moldovan، نويسنده , , Paula and Nov?k، نويسنده , , Lajos and Kolonits، نويسنده , , P?l and Szab?، نويسنده , , Eva and Poppe، نويسنده , , L?szl? and Irimie، نويسنده , , Florin-Dan Irimie، نويسنده ,
Abstract :
A series of 10-alkyl-10H-phenothiazine-3-carbaldehydes (2a–h) were obtained by Vilsmeier–Haack formylation from the corresponding 10-alkyl-10H-phenothiazines (1a–h) and reduced to (10-alkyl-10H-phenothiazine-3-yl)methanols (3a–h) by two alternative methods. The baker’s yeast catalyzed reaction proved to be superior over the NaBH4 reduction and yielded the desired 3-hydroxymethylphenothiazines (3a–h) almost quantitatively.
Keywords :
N-alkylphenothiazines , Aldehydes , Formylation , Baker’s yeast , Reduction
