Title of article
Microbial transformation of deoxyandrographolide by Cunninghamella echinulata
Author/Authors
Li، نويسنده , , Feng Yun and Cang، نويسنده , , Peter R. and Huang، نويسنده , , Shan Shan and Zhang، نويسنده , , Bao Jing and Xin، نويسنده , , Xiu Lan and Yao، نويسنده , , Ji Hong and Zhou، نويسنده , , Qi and Tian، نويسنده , , Yan and Deng، نويسنده , , Sha and Ma، نويسنده , , Xiao Chi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
5
From page
187
To page
191
Abstract
The capabilities of twenty strains of filamentous fungi (from 9 genera) to transform deoxyandrographolide (1) were screened. And eleven derivatives of 1 transformed by Cunninghamella echinulata AS 3.3400 were isolated. Their chemical structures were identified by spectral methods including 2D NMR. Among them, 3-oxo-7α-hydroxy-14-deoxyandrographolide (2), 3-oxo-8β,17α-epoxy-14-deoxyandrographolide (3), 8α-formyl-14-deoxyandrographolide (4), 8β-methoxyl-17α-hydroxyl-14-deoxyandro-grapholide (5) and 3α,17,19-trihydroxyl-7,13-ent-labdadien-15,16-olide (6), are new compounds. And their structure–activity relationships (SAR) were also discussed.
Keywords
Microbial transformation , Deoxyandrographolide , hydroxylation , Ent-labdane
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2011
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1716961
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