Title of article
Enzymatic radiofluorination: Fluorinase accepts methylaza-analog of SAM as substrate for FDA synthesis
Author/Authors
Sergeev، نويسنده , , Maxim E. and Morgia، نويسنده , , Federica and Javed، نويسنده , , Muhammad R. and Doi، نويسنده , , Mami and Keng، نويسنده , , Pei Y. Tong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
6
From page
74
To page
79
Abstract
Methylaza-analog of S-adenosyl-l-methionine (MeAzaAdoMet) was found to be a substrate for fluorinase. This is the first discovery of a new substrate for fluorinase that can be accessed synthetically in high purity. The activity of fluorinase for the new MeAzaAdoMet and [18F]fluoride ion was 32% in 180 min.
Keywords
Substrate Specificity , Fluorinase , Enzymatic catalysis , Nucleophilic fluorination
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2013
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1718220
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