Title of article :
Enzymatic radiofluorination: Fluorinase accepts methylaza-analog of SAM as substrate for FDA synthesis
Author/Authors :
Sergeev، نويسنده , , Maxim E. and Morgia، نويسنده , , Federica and Javed، نويسنده , , Muhammad R. and Doi، نويسنده , , Mami and Keng، نويسنده , , Pei Y. Tong، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Abstract :
Methylaza-analog of S-adenosyl-l-methionine (MeAzaAdoMet) was found to be a substrate for fluorinase. This is the first discovery of a new substrate for fluorinase that can be accessed synthetically in high purity. The activity of fluorinase for the new MeAzaAdoMet and [18F]fluoride ion was 32% in 180 min.
Keywords :
Substrate Specificity , Fluorinase , Enzymatic catalysis , Nucleophilic fluorination
Journal title :
Journal of Molecular Catalysis B Enzymatic
Journal title :
Journal of Molecular Catalysis B Enzymatic
