Author/Authors :
Coronel، نويسنده , , Camila and Arce، نويسنده , , Gabriel and Iglesias، نويسنده , , Cesar and Noguera، نويسنده , , Cynthia Magallanes and Bonnecarrère، نويسنده , , Paula Rodriguez and Giordano، نويسنده , , Sonia Rodrيguez and Gonzalez، نويسنده , , David، نويسنده ,
Abstract :
Five endophytic yeast strains isolated from edible plants were tested in the reduction β-chloro- and β-azidopropiophenone for the preparation of optically active fluoxetine precursors. The biotransformation rendered not only the corresponding chiral γ-substituted alcohols, but also unsubstituted alcohols and ketones. The product profile was studied and a plausible mechanism for the reductive elimination of the β-functional group is proposed.
