Author/Authors :
de Oliveira Lopes، نويسنده , , Raquel Matos de Miranda Torrinhas، نويسنده , , Amanda S. and Reichart، نويسنده , , Benedikt and Glasnov، نويسنده , , Toma and Kappe، نويسنده , , C. Oliver and Simon، نويسنده , , Robert C. and Kroutil، نويسنده , , Wolfgang and Miranda، نويسنده , , Leandro S.M. and Leal، نويسنده , , Ivana C.R. and de Souza، نويسنده , , Rodrigo O.M.A.، نويسنده ,
Abstract :
The development of chemo-enzymatic reaction under continuous flow conditions is an emerging area where biotechnology and organic chemistry can joint efforts in order to develop better process. Here in we report our effort on the development of a continuous flow approach to the synthesis of Odanacatib intermediate using a combined batch and continuous flow apparatus arriving on the desired molecule in excellent yields and selectivity.
Keywords :
Odanacatib , Continuous process , Cascade reaction , Flow chemistry , Bioreduction
