Title of article :
TOPS-MODE approach to predict mutagenicity in dental monomers
Author/Authors :
Helguera، نويسنده , , Aliuska Morales and Gonzلlez، نويسنده , , Maykel Pérez and Briones، نويسنده , , Jaques Rieumont، نويسنده ,
Issue Information :
دوهفته نامه با شماره پیاپی سال 2004
Abstract :
The TOPological Sub-Strutural Molecular Design (TOPS-MODE) approach has been introduced for the study of mutagenic properties. The mutagenicity of 23 dental monomers was studied with this approach obtaining a good quantitative structure–toxicity model. For the comparison were involved four different weights in the diagonal entries of the bond matrix for selecting the best TOPS-MODE model. TOPS-MODE was used to derive the contribution of different fragments to the toxicity of studied compounds.
Keywords :
monomers , Mutagenicity , QSAR
