Title of article :
A topological sub-structural approach of the mutagenic activity in dental monomers. 1. Aromatic epoxides
Author/Authors :
Gonz?lez، نويسنده , , Maykel Pérez and Helguera، نويسنده , , Aliuska Morales and Ruiz، نويسنده , , Reinaldo Molina and Garc??a F?rdales، نويسنده , , José R.، نويسنده ,
Issue Information :
دوهفته نامه با شماره پیاپی سال 2004
Abstract :
The topological sub-structural molecular design (TOPS-MODE) approach has been introduced for the study of mutagenic properties. The mutagenicity of 16 dental monomers was studied with this approach, obtaining a good quantitative structure–toxicity model. For comparison, four different weights were involved in the diagonal entries of the bond matrix for selecting the best TOPS-MODE model. TOPS-MODE was used to derive the contribution of different fragments to the toxicity of studied compounds.
Keywords :
Quantitative structure–activity relationships , Aromatic Epoxides , Mutagenicity
